Four childhood friends travel to an inherited cabin to relive old memories, but what begins as a nostalgic getaway turns terrifying after they find the mutilated remains of a park ranger on the property. As strange tremors shake the forest floor and massive tracks circle the cabin, the girls uncover that the land sits atop a breeding site for an enormous, centuries-old anaconda. When one of them accidentally disturbs a hidden clutch of newborn snakes, the protective mother bursts from the swamp, beginning a deadly hunt that forces the group to brave the wilderness and unravel the history of the cursed land to survive.